Plants contain a huge number of flavonoids, and diosmin, a flavone glycoside, is a flavonoid found in citrus fruits. Diosmin was first found in 1925 in the wort plant and has since been used as a natural treatment for hemorrhoids, varicose veins, venous insufficiency, leg ulcers, and other circulatory issues.
The most commonly used and widely studied venoactive drug (VAD) is micronized purified flavonoid fraction (MPFF), and it has found to be effective at all stages of chronic venous disease. It has been shown to significantly reduce leg pain and leg heaviness and swelling, as well as ankle oedema and functional discomfort, in clinical trials. Experiments employing animal models of CVD have demonstrated that MPFF has anti-inflammatory and venotonic effects at the microvalve level, and a pilot clinical study in patients with CVD has provided support for these findings. Collectively, these results suggest that early initiation of MPFF treatment may have the potential to favourably alter the clinical course of the disease, although further clinical data are required to confirm these findings. International guidelines on CVD management strongly recommend MPFF to reduce symptoms and improve quality of life. Studies are now needed to investigate the impact of long-term treatment on disease progression.
Diosmin is a VAD that works on blood vessels in a variety of ways to improve circulation. It improves lymphatic drainage and microcirculation, as well as venous tone and suppleness. It is often used to improve vascular health in people with chronic venous disease for these reasons, and it has been demonstrated to improve quality of life. Diosmin also has antioxidant characteristics and scavenges oxygen free radicals, lowering oxidative stress levels that can be detected by biomarkers such as prostaglandin isoprostane precursors
Diosmin is an anti-oxidant, anti-cancer, anti-diabetic, and mild anti-bacterial flavone glycoside derived from citrus trees. Because of its characteristics, it is a good therapeutic treatment for a variety of disorders. It reduces oxidative stress by altering the activity of particular enzymes and promotes apoptosis in a variety of cancer cell lines via several ways. Its anti-inflammatory properties are due to its ability to lower the levels of numerous inflammation markers. It also helps alleviate the consequences of diabetes, such as neuropathy and dyslipidemia. It has been found to be quite useful in the treatment of chronic venous insufficiency and hemorrhoids when combined with other flavonoids, particularly hesperidin.
Recommended by Dr. Karen Herbst, 500 mg to 900 mg by mouth once or twice daily.
Diosmin. (n.d.) Drugs.com.
Diosmin. (n.d.) Healthline.
Diosmin. (n.d.) National Library of Medicine.
Huwait, E., and Mobashir, M. (2022, May 6). Potential and therapeutic roles of diosmin in human diseases. Biomedicines. PMC9138579.
Research
Effect of diosmin administration in patients with chronic venous disorders on selected factors affecting angiogenesis | M. Feldo, M. Wojciak-Kosior, I. Sowa, J. Kocki, J. Bogucki, T. Zubilewicz, … and A. Bogucka-Kocka (2019)
Micronised purified flavonoid fraction: A review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids | K. Lyseng-Williamson and C. Perry (2012)
New perspectives on micronised purified flavonoid fraction in chronic venous disease: From microvalves to clinical effectiveness | E. Bouskela, M. Lugli and A. Nicolaides (2022)
Potential and therapeutic roles of diosmin in human diseases. | E. Huwait and M. Mobashir (2022)
Vasculera
Vasculera (diosmiplex) is a prescription medical food containing purified diosmin (MPFF), a high-quality ingredient that has been designated “generally recognized as safe” (GRAS), the highest standard of safety. Diosmin (MPFF) is a flavonoid isolated from hesperidin, found in citrus, that restores the body’s microcirculatory balance.
Recommended by Dr. Karen Herbst.
Save on Vasculera. $132 for 3 months’ supply.
Primus Care Direct is a hassle-free, mail-order pharmacy service where patients can get their Vasculera prescription for $49 for a 30-day supply or $132 for a 90-day supply ($44 per month), Medicare patients included. This is the lowest possible price available and includes free home delivery. If you have insurance coverage for prescription medical foods, you may pay even less. Vasculera Prescribing Information
Blink Pharmacy Plus also offers a discount on Vasculera.
